Jun Lu Selected Research

Phosphotransferases (Kinase)

3/2024	Hybridization-based discovery of novel quinazoline-2-indolinone derivatives as potent and selective PI3Kα inhibitors.
6/2023	[Effect of acupuncture on protein kinase R-like endoplasmic reticulum kinase/eukaryotic translation initiation factor 2α signaling pathway in hippocampus of rats with post-traumatic stress disorder].
10/2021	Akt kinase LANCL2 functions as a key driver in EGFR-mutant lung adenocarcinoma tumorigenesis.
1/2021	PI3K/Akt pathway and Nanog maintain cancer stem cells in sarcomas.
1/2021	Pan-cancer Analysis of NEDD4L and Its Tumor Suppressor Effects in Clear Cell Renal Cell Carcinoma.
5/2019	Overexpression of IC53d promotes the proliferation of gastric cancer cells by activating the AKT/GSK3β/cyclin D1 signaling pathway.
2/2019	High-throughput screening of novel pyruvate dehydrogenase kinases inhibitors and biological evaluation of their in vitro and in vivo antiproliferative activity.
1/2018	Adeno-associated virus vector-mediated expression of DJ-1 attenuates learning and memory deficits in 2, 2´, 4, 4´-tetrabromodiphenyl ether (BDE-47)-treated mice.
1/2017	Molecular mechanism of G1 arrest and cellular senescence induced by LEE011, a novel CDK4/CDK6 inhibitor, in leukemia cells.
11/2011	Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice.

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Jun Lu Research Topics

Disease

408	Neoplasms (Cancer) 05/2024 - 03/2002
204	Stomach Neoplasms (Stomach Cancer) 05/2024 - 02/2010
76	Neoplasm Metastasis (Metastasis) 12/2023 - 09/2009
62	Inflammation (Inflammations) 05/2024 - 11/2003
50	Breast Neoplasms (Breast Cancer) 03/2024 - 10/2003
40	Infections 04/2024 - 11/2005
39	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2024 - 06/2016
38	Carcinogenesis 03/2024 - 05/2007
33	Adenocarcinoma 02/2024 - 01/2009
31	Leukemia 12/2023 - 09/2007
29	Hepatocellular Carcinoma (Hepatoma) 02/2024 - 04/2002
29	Carcinoma (Carcinomatosis) 04/2023 - 02/2002
28	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 02/2024 - 12/2007
26	Hemorrhage 02/2024 - 01/2012
24	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 04/2024 - 12/2007
23	Body Weight (Weight, Body) 03/2024 - 12/2006
22	Type 2 Diabetes Mellitus (MODY) 01/2024 - 09/2005
22	Colorectal Neoplasms (Colorectal Cancer) 11/2023 - 02/2011
21	Glioma (Gliomas) 09/2023 - 02/2014
20	Sepsis (Septicemia) 02/2024 - 12/2004
20	Osteoarthritis 01/2024 - 11/2014
18	Obesity 03/2024 - 03/2011
18	Pancreatic Neoplasms (Pancreatic Cancer) 11/2023 - 01/2009
18	Lung Neoplasms (Lung Cancer) 07/2022 - 05/2009
16	Insulin Resistance 08/2023 - 12/2010
15	Renal Cell Carcinoma (Grawitz Tumor) 02/2024 - 03/2017
15	Ischemic Stroke 01/2024 - 05/2016
15	Prostatic Neoplasms (Prostate Cancer) 06/2023 - 10/2002
14	Fibrosis (Cirrhosis) 03/2024 - 11/2003
14	Heart Failure 06/2023 - 12/2006
14	Liver Neoplasms (Liver Cancer) 01/2023 - 02/2002
13	Myasthenia Gravis 01/2024 - 06/2012
13	Adenocarcinoma of Lung 01/2022 - 01/2018
13	Hypoxia (Hypoxemia) 01/2021 - 07/2005
13	Melanoma (Melanoma, Malignant) 01/2021 - 03/2002
12	Reperfusion Injury 04/2024 - 11/2010
11	Cognitive Dysfunction 02/2024 - 01/2009
11	Hypertension (High Blood Pressure) 01/2024 - 05/2004
11	Pain (Aches) 03/2023 - 09/2005
11	Flatulence 04/2017 - 12/2012
10	Hyperglycemia 03/2024 - 08/2007
10	Stroke (Strokes) 01/2024 - 06/2008
10	Ovarian Neoplasms (Ovarian Cancer) 12/2023 - 03/2002
10	Colonic Neoplasms (Colon Cancer) 12/2023 - 03/2014
10	Mitochondrial Diseases (Mitochondrial Disease) 12/2023 - 09/2009
10	Autoimmune Diseases (Autoimmune Disease) 10/2023 - 01/2016
10	Diabetes Mellitus 01/2023 - 08/2007
10	Thrombosis (Thrombus) 01/2023 - 05/2015
10	Septic Shock (Toxic Shock Syndrome) 01/2022 - 12/2004

Drug/Important Bio-Agent (IBA)

118	Proteins (Proteins, Gene)FDA Link 01/2024 - 09/2002
67	MicroRNAs (MicroRNA)IBA 02/2024 - 06/2005
62	Biomarkers (Surrogate Marker)IBA 12/2024 - 01/2009
41	Long Noncoding RNAIBA 04/2024 - 11/2014
34	Messenger RNA (mRNA)IBA 02/2024 - 10/2003
33	CytokinesIBA 05/2023 - 12/2004
30	Glucose (Dextrose)FDA LinkGeneric 01/2024 - 08/2002
27	DNA (Deoxyribonucleic Acid)IBA 05/2024 - 03/2002
25	EnzymesIBA 01/2023 - 03/2003
20	RNA (Ribonucleic Acid)IBA 02/2024 - 01/2018
20	Small Interfering RNA (siRNA)IBA 07/2023 - 09/2005
19	Indicators and Reagents (Reagents)IBA 03/2024 - 09/2013
19	Therapeutic UsesIBA 01/2023 - 05/2003
17	Immune Checkpoint InhibitorsIBA 05/2024 - 11/2020
17	LipidsIBA 01/2024 - 08/2002
17	Peptides (Polypeptides)IBA 01/2024 - 10/2002
16	AntioxidantsIBA 08/2023 - 07/2005
16	AntigensIBA 04/2023 - 03/2002
16	Circular RNAIBA 01/2023 - 01/2018
16	CateninsIBA 01/2023 - 10/2015
15	Phosphotransferases (Kinase)IBA 03/2024 - 09/2002
15	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2024 - 12/2006
14	Paclitaxel (Taxol)FDA LinkGeneric 01/2024 - 09/2002
14	Insulin (Novolin)FDA Link 10/2023 - 03/2011
13	Reactive Oxygen Species (Oxygen Radicals)IBA 02/2024 - 01/2011
12	LipopolysaccharidesIBA 02/2024 - 08/2003
12	Interleukin-6 (Interleukin 6)IBA 01/2024 - 04/2003
12	anlotinibIBA 04/2023 - 01/2019
11	ChemokinesIBA 01/2023 - 11/2008
11	Caspase 3 (Caspase-3)IBA 04/2021 - 09/2002
10	Blood Glucose (Blood Sugar)IBA 02/2024 - 08/2007
10	LigandsIBA 02/2024 - 07/2013
10	C-Reactive ProteinIBA 01/2024 - 03/2006
10	AlbuminsIBA 03/2023 - 08/2005
10	Triglycerides (Triacylglycerol)IBA 05/2021 - 08/2002
9	Anti-Bacterial Agents (Antibiotics)IBA 05/2024 - 03/2012
9	Oxygen (Dioxygen)IBA 03/2024 - 11/2006
9	CholesterolIBA 03/2024 - 08/2002

Therapy/Procedure

178	Therapeutics 05/2024 - 04/2003
119	Gastrectomy 04/2024 - 10/2012
81	Drug Therapy (Chemotherapy) 04/2024 - 05/2006
55	Lymph Node Excision (Lymph Node Dissection) 05/2024 - 10/2012
34	Adjuvant Chemotherapy 05/2024 - 10/2014
28	Immunotherapy 01/2024 - 08/2002
22	Radiotherapy 01/2024 - 09/2005
18	Neoadjuvant Therapy 04/2024 - 05/2016
14	Transplantation 01/2024 - 11/2005
14	Length of Stay 04/2023 - 12/2012
14	Chinese Traditional Medicine (Traditional Chinese Medicine) 04/2021 - 06/2007
12	Stents 08/2021 - 02/2007
11	Hematopoietic Stem Cell Transplantation 02/2024 - 08/2015